Induction of Delayed-Type Hypersensitivity to Staphylococcal Antigens in Guinea Pigs
نویسندگان
چکیده
منابع مشابه
THE EFFECT OF ASCORBIC ACID ON BLOOD HISTAMINE LEVEL AND DELAYED-TYPE HYPERSENSITIVITY IN GUINEA PIGS
The effect of ascorbic acid on blood histamine level and delayed-type hypersensitivity was studied in thirty male guinea pigs. Animals were sensitized to B.C.G., trichophytin and mallein during the first four weeks. The diet was ad libitum during this period. After this "sensitization period" animals w er e tested intradermally with tuberculin, trichophytin and mallein. The number and diam...
متن کاملAntibody-mediated and delayed-type hypersensitivity reactions to Brucella skin test antigens in guinea pigs.
Cutaneous hypersensitivity responses to brucella antigens of different composition were studied in guinea pigs sensitized by infection with smooth brucella or immunization with killed rough brucella in adjuvant. These animals had circulating antibodies to smooth lipopolysaccharide or protein antigens, respectively. Intradermal skin tests, active cutaneous anaphylaxis, passive cutaneous anaphyl...
متن کاملDelayed Hypersensitivity Induced in Guinea Pigs
A delayed hypersensitivity to 7,12-dimethylbenz(a)anthracene was elicited in guinea pigs after contact sensitization. This sensitivity was characterized by its time of appearance, histology, specificity, and transfer characteristics. The reaction had its maximal dermal reactivity 24 hr after challenge, was characterized by a mononuclear cell infiltration, demonstrated immunological specificity,...
متن کاملEvaluation of Recombinant Mycobacterium tuberculosis Antigens MPT64, CFP10, and ESAT6 for Delayed-Type Hypersensitivity Responses in Guinea Pigs
The tuberculin Purified Protein Derivative (PPD) skin test is widely used; however, the results are often inaccurate. Positive results can be observed in patients with active tuberculosis (TB) as well as in BCG-vaccinated persons and individuals who are infected with mycobacteria but have not developed the disease. MPT64, an antigen secreted from actively growing Mycobacterium tuberculosis and ...
متن کاملEvaluation of Mycobacterium tuberculosis specific RD antigens for delayed type hypersensitivity responses in guinea pig.
Tuberculin skin test (TST), an age old method is based on measuring delayed-type hypersensitivity (DTH) response to purified protein derivative (PPD). However, inspite of simplicity, ease and cost effectiveness, the usefulness of PPD test is limited due to its inability to distinguish among a protective immune response, latent infection and active tuberculosis disease. On the other hand, a skin...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1978
ISSN: 0022-202X
DOI: 10.1111/1523-1747.ep12546488